Ro 5-3335
Ro 5-3335 is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM) . It represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. It also reduces the leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. It also is a Tat antagonist and inhibits HIV-1 replication in vitro.
Product Specifications
CAS Number
30195-30-3
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (385.07 mM)
Smiles
Clc1ccc2NC (=O) CN=C (c2c1) c3cccn3
Molecular Formula
C13H10ClN3O
Molecular Weight
259.69
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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