IMR-1
IMR-1 is a Mastermind Recruitment inhibitor. IMR-1 disrupted the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex on chromatin, thereby attenuating Notch target gene transcription. IMR-1 inhibited the growth of Notch-dependent cell lines and significantly abrogated the growth of patient-derived tumor xenografts.
Product Specifications
CAS Number
310456-65-6
Product Name Alternative
IMR-1 | IMR 1 | IMR1. Inhibitor of Mastermind Recruitment-1
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 100 mg/mL 282.96 mM; H2O : < 0.1 mg/mL
Smiles
C (=O) (COc1c (cc (cc1) /C=C/1\SC (=S) NC1=O) OC) OCC
Molecular Formula
C15H15NO5S2
Molecular Weight
353.41
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(E) -Ethyl 2- (2-methoxy-4- ((4-oxo-2-thioxothiazolidin-5-ylidene) methyl) phenoxy) acetate
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