FLI-06
FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A. FLI-06 inhibits general secretion at a step before exit from the endoplasmic reticulum (ER), which was accompanied by a tubule-to-sheet morphological transition of the ER. FLI-06 is the first small molecule acting at such an early stage in secretory traffic. Notch signaling has a pivotal role in numerous cell-fate decisions, and its aberrant activity leads to developmental disorders and cancer.
Product Specifications
CAS Number
313967-18-9
Product Name Alternative
FLI06 | FLI 06 | FLI06
Field of Research
Musculoskeletal & Connective Tissue Research
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 38 mg/mL; 86.66 mM
Smiles
CC1=C (C (c2ccc (cc2) [N+] (=O) [O-]) C2=C (CC (C) (C) CC2=O) N1) C (=O) OC1CCCCC1
Molecular Formula
C25H30N2O5
Molecular Weight
438.52
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Cyclohexyl 2,7,7-trimethyl-4- (4-nitrophenyl) -5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
Available Sizes
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