TCS 5861528
TCS-5861528, also known as Chembridge-5861528, is a TRPA1 receptor antagonist. TCS-5861528 antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively) . TRPA1 was found to mediate acute inflammation and the development of degenerative cartilage changes and joint pain in MIA-induced experimental OA in the mouse. TRPA1 may be a potential mediator and drug target in OA.
Product Specifications
CAS Number
332117-28-9
Product Name Alternative
TCS5861528, TCS-5861528
Purity
>98% (HPLC)
Solubility
DMSO : 74 mg/mL. 200.31 mM
Smiles
CCC (C) c1ccc (NC (=O) Cn2cnc3c2c (=O) n (C) c (=O) n3C) cc1
Molecular Formula
C19H23N5O3
Molecular Weight
369.42
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl) -N-[4- (1-methylpropyl) phenyl]acetamide
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