CCF642
CCF-642 is a protein disulfide isomerase (PDI) inhibitor. CCF642 exhibited a submicromolar IC50 in 10 of 10 multiple myeloma cell lines. In vitro, CCF642 inhibited PDI reductase activity about 100-fold more potently than the structurally distinct established inhibitors PACMA 31 and LOC14. CCF642 displayed potent efficacy in an aggressive syngeneic mouse model of multiple myeloma and prolonged the lifespan of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma, an effect comparable to the first-line multiple myeloma therapeutic bortezomib.
Product Specifications
CAS Number
346640-08-2
Product Name Alternative
CCF-642 | CCF 642 | CCF642
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 30 mg/mL; 79.27 mM
Smiles
S1C (=S) N (C (=O) /C/1=C\c1ccc (s1) [N+] (=O) [O-]) c1ccc (cc1) OC
Molecular Formula
C15H10N2O4S3
Molecular Weight
378.45
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3- (4-Methoxyphenyl) -5-[ (5-nitro-2-thienyl) methylene]-2-thioxo-4-thiazolidinone
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