Madrasin
Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin stalls spliceosome assembly at the A complex. (In Vitro) :Madrasin (10-30 μM; 4-24 hours; HeLa cells) treatment inhibits the splicing of each of the RIOK3, BRD2, and Hsp40, MCL1, CCNA2, AURKA and p27 pre-mRNAs in both HeLa and HEK293 cells.Madrasin (10-30 μM; 4-24 hours; HeLa and HEK293 cells) treatment shows a dose- and time-dependent inhibitory effect on cell cycle progression.
Product Specifications
CAS Number
374913-63-0
Product Name Alternative
DDD00107587 | Madrasin. RNA splicing inhibitor
Purity
>98% (HPLC)
Solubility
H2O : < 0.1 mg/mL
Smiles
O=c1[nH]c (Nc2nc (C) c3ccc (OC) cc3n2) nc (C) c1C
Molecular Formula
C16H17N5O2
Molecular Weight
311.34
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- ((7-Methoxy-4-methylquinazolin-2-yl) amino) -5,6-dimethylpyrimidin-4 (3H) -one
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