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ISO-1

ISO-1, also known as MIF Antagonist and ISO-1 and Macrophage Migration Inhibitory Factor, is a MIF inhibitor. ISO-1 has CAS#478336-92-4. MDK-6924 Protects Photoreceptors and Reduces Gliosis in Experimental Retinal Detachment. Systemic administration of the MIF inhibitor ISO-1 significantly blocked photoreceptor apoptosis, outer nuclear layer (ONL) thinning, and retinal gliosis. ISO-1 and MIF knockout (MIFKO) had greater accumulation of Müller glia pERK expression in the detached retina, suggesting that Müller survival pathways might underlie the neuroprotective response.

Product Specifications

CAS Number

478336-92-4

Product Name Alternative

ISO-1 | ISO 1 | ISO1 | MIF Antagonist

Purity

>98% (HPLC)

Solubility

DMSO : ≥ 36 mg/mL; 153.04 mM

Smiles

COC (=O) CC1CC (=NO1) c1ccc (O) cc1

Molecular Formula

C12H13NO4

Molecular Weight

235.2

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

4,5-dihydro-3- (4-hydroxyphenyl) -5-isoxazoleacetic acid, methyl ester

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