Rolapitant
Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP) . This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV) . The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy. Compared to other NK1-receptor antagonists, rolapitant has both a more rapid onset of action and a much longer half-life.
Product Specifications
CAS Number
552292-08-7
Product Name Alternative
SCH619734
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 30 mg/mL; 59.94 mM
Smiles
C[C@H] (c1cc (cc (c1) C (F) (F) F) C (F) (F) F) OC[C@]1 (CC[C@]2 (CCC (=O) N2) CN1) c1ccccc1
Molecular Formula
C25H26F6N2O2
Molecular Weight
500.48
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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