CHIR98014
CHIR98014, also known as CT-98024, is a reversible, cell-permeable inhibitor of GSK3α and GSK3β (IC50 = 0.65 and 0.58 nM, respectively) . It is inactive against a series of other serine/threonine or tyrosine kinases. Through its effects on GSK3, CHIR98014 stimulates glycogen synthase in cells (EC50 = 106 nM), potentiates insulin-dependent glucose transport in isolated muscle strips, and improves glucose disposal in diabetic animals. CHIR98014 also reduces tau phosphorylation in rat brains and supports Wnt signaling during osteogenesis.
Product Specifications
CAS Number
556813-39-9
Product Name Alternative
CHIR98014 | CHIR-98014 | CHIR 98014
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 125 mg/mL (257.04 mM)
Smiles
C1cc (c (cc1Cl) Cl) c1nc (ncc1c1[nH]ccn1) NCCNc1nc (c (cc1) [N+] (=O) [O-]) N
Molecular Formula
C20H17Cl2N9O2
Molecular Weight
486.31
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N2- (2- ((4- (2,4-dichlorophenyl) -5- (1H-imidazol-2-yl) pyrimidin-2-yl) amino) ethyl) -5-nitropyridine-2,6-diamine
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