Halofuginone
Halofuginone, also known as RU-19110, is a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters.
Product Specifications
CAS Number
55837-20-2
Product Name Alternative
RU 19110 | RU19110 | Halofuginone | Tempostatin
Purity
>98% (HPLC)
Solubility
DMSO : 9 mg/mL. 21.70 mM
Smiles
C1C[C@H] ([C@@H] (NC1) CC (=O) Cn1cnc2cc (c (cc2c1=O) Cl) Br) O
Molecular Formula
C16H17BrClN3O3
Molecular Weight
414.68
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
7-bromo-6-chloro-3- (3- ((2S,3R) -3-hydroxypiperidin-2-yl) -2-oxopropyl) quinazolin-4 (3H) -one.
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