Halofuginone
Halofuginone, also known as RU-19110, is a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters.
Product Specifications
CAS Number
55837-20-2
Product Name Alternative
RU 19110 | RU19110 | Halofuginone | Tempostatin
Purity
>98% (HPLC)
Solubility
DMSO : 9 mg/mL. 21.70 mM
Smiles
C1C[C@H] ([C@@H] (NC1) CC (=O) Cn1cnc2cc (c (cc2c1=O) Cl) Br) O
Molecular Formula
C16H17BrClN3O3
Molecular Weight
414.68
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
7-bromo-6-chloro-3- (3- ((2S,3R) -3-hydroxypiperidin-2-yl) -2-oxopropyl) quinazolin-4 (3H) -one.
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
TNF-alpha (APC1, Cachectin, Differentiation inducing factor (DIF), Macrophage cytotoxic factor (MCF), Necrosin, TNF alpha, TNF Macrophage Derived, TNF Monocyte Derived, TNF Superfamily Member 2, TNFA, TNFSF2, Tumor necrosis factor ligand superfamily member 2, Tumor Necrosis Factor Precursor) (BSA & Azide Free) (MaxLight 550)
