Cucurbitacin B
Cucurbitacin B is a plant-derived triterpene that has the classic four-ring structure of mammalian steroids. Cucurbitacin B suppresses metastasis mediated by reactive oxygen species (ROS) via focal adhesion kinase (FAK) in breast cancer MDA-MB-231 cells. Cucurbitacin B induces inhibitory effects via CIP2A/PP2A/Akt pathway in glioblastoma multiforme. Cucurbitacin B acts a potential insect growth regulator by antagonizing 20-hydroxyecdysone activity.
Product Specifications
CAS Number
6199-67-3
Product Name Alternative
Cucurbitacin B | Cuc B | NSC 49451
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 100 mg/mL 178.99 mM; H2O : < 0.1 mg/mL
Smiles
C (=O) (C) OC (C) (/C=C/C (=O) [C@] (C) (O) [C@H]1[C@@H] (C[C@]2 ([C@@H]3CC=C4C (C (=O) [C@H] (C[C@H]4[C@@]3 (C (=O) C[C@]12C) C) O) (C) C) C) O) C
Molecular Formula
C32H46O8
Molecular Weight
558.7
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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