What is the catalog number for VCMMAE?

The catalog number for VCMMAE is orb1223083.

What sizes are available for VCMMAE?

VCMMAE is available in the following size(s): 200 mg, 500 mg, 1 g, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg.

How many pack sizes does VCMMAE come in?

VCMMAE is available in 8 different pack sizes.

VCMMAE is currently made to order / not held in immediate stock. Contact us for lead time.

VCMMAE

VcMMAE is a MMAE derivative with valine-citrulline (Vc) linker. VcMMAE can be used to make antibody drug conjugate. VcMMAE is a anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc) . Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. These drugs show potency of up to 200 times that of vinblastine, another antimitotic drug used for Hodgkin lymphoma as well as other types of cancer.

Product Specifications

CAS Number

646502-53-6

Product Name Alternative

VcMMAE | Vc-MMAE | MMAE Vc linker

Purity

>98% (HPLC)

Solubility

DMSO : ≥ 54 mg/mL; 41.01 mM

Smiles

CC[C@H] (C) [C@@H] ([C@@H] (CC (=O) N1CCC[C@H]1[C@H] (OC) [C@@H] (C) C (=O) N[C@H] (C) [C@@H] (O) c1ccccc1) OC) N (C) C (=O) [C@@H] (NC (=O) [C@H] (C (C) C) N (C) C (=O) OCc1ccc (NC (=O) [C@H] (CCCNC (N) =O) NC (=O) [C@@H] (NC (=O) CCCCCN2C (=O) C=CC2=O) C (C) C) cc1) C (C) C

Molecular Formula

C68H105N11O15

Molecular Weight

1316.65

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

4- ((S) -2- ((S) -2- (6- (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl) hexanamido) -3-methylbutanamido) -5-ureidopentanamido) benzyl ((S) -1- (((S) -1- (((3R,4S,5S) -1- ((S) -2- ((1R,2R) -3- (((1S,2R) -1-hydroxy-1-phenylpropan-2-yl) amino) -1-methoxy-2-methyl-3-oxopropyl) pyrrolidin-1-yl) -3-methoxy-5-methyl-1-oxoheptan-4-yl) (methyl) amino) -3-methyl-1-oxobutan-2-yl) amino) -3-methyl-1-oxobutan-2-yl) (methyl) carbamate