AS-604850
AS-604850 is a selective PI3Kγ inhibitor, which significantly reduced the number of infiltrated leukocytes in the CNS and ameliorated the clinical symptoms of EAE mice. Treatment with this PI3Kγ inhibitor enhanced myelination and axon number in the spinal cord of EAE mice. PI3Kγ contributes to development of autoimmune CNS inflammation and that PI3Kγ blockade may provide a great potential for treating patients with MS.
Product Specifications
CAS Number
648449-76-7
Product Name Alternative
AS604850 | AS 604850 | AS-604850
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 250 mg/mL (876.52 mM)
Smiles
C1cc2c (cc1/C=C\1/C (=O) NC (=O) S1) OC (O2) (F) F
Molecular Formula
C11H5F2NO4S
Molecular Weight
285.22
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(Z) -5- ((2,2-difluorobenzo[d][1,3]dioxol-5-yl) methylene) thiazolidine-2,4-dione
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