CHF5074
CHF-5074, also known as CSP-1103, is a γ-secretase modulator. CHF-5074 reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM respectively. CHF5074 reduces brain beta-Amyloid pathology in a transgenic mouse model of Alzheimer's Disease without causing peripheral toxicity. CHF5074 is a non-steroidal anti-inflammatory derivative holding disease-modifying potential for the treatment of Alzheimer's disease.
Product Specifications
CAS Number
749269-83-8
Product Name Alternative
CHF-5074 | CHF5074 | CHF 5074 | CSP-1103
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 37 mg/mL; 113.79 mM
Smiles
Clc1cc (c2c (F) cc (C3 (CC3) C (=O) O) cc2) ccc1Cl
Molecular Formula
C16H11Cl2FO2
Molecular Weight
325.16
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-[4- (3,4-dichlorophenyl) -3-fluorophenyl]cyclopropane-1-carboxylic acid
Available Sizes
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