TPI-1
TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor. TPI-1 selectively increased SHP-1 phospho-substrates (pLck-pY394, pZap70, and pSlp76) in Jurkat T cells but had little effects on pERK1/2 or pLck-pY505 regulated by phosphatases SHP-2 or CD45, respectively. TPI-1 induced mouse splenic-IFN-gamma (+) cells in vitro, approximately 58-fold more effective than sodium stibogluconate, and increased mouse splenic-pLck-pY394 and -IFN-gamma (+) cells in vivo.
Product Specifications
CAS Number
79756-69-7
Product Name Alternative
TPI-1 | TPI 1 | Tyrosine Phosphatase Inhibitor 1
Field of Research
Metabolism Research
Purity
>98% (HPLC)
Solubility
DMSO : 50 mg/mL 197.57 mM
Smiles
C1cc (c (cc1Cl) C1=CC (=O) C=CC1=O) Cl
Molecular Formula
C12H6Cl2O2
Molecular Weight
253.08
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (2,5-dichlorophenyl) -2,5-cyclohexadiene-1,4-dione
Available Sizes
Frequently Asked Questions
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