SSR128129E
SSR128129E (SSR) is an potent FGFR inhibitor, which inhibits fibroblast growth factor receptor (FGFR) signaling by binding to the extracellular FGFR domain without affecting orthosteric FGF binding. SSR128129E exhibits allosteric properties, including probe dependence, signaling bias, and ceiling effects. Inhibition by SSR128129E is highly conserved throughout the animal kingdom. Oral delivery of SSR128129E inhibits arthritis and tumors that are relatively refractory to anti-vascular endothelial growth factor receptor-2 antibodies. Thus, orally-active extracellularly acting small-molecule modulators of RTKs with allosteric properties can be developed and may offer opportunities to improve anticancer treatment.
Product Specifications
CAS Number
848318-25-2
Product Name Alternative
SSR128129E | SSR 128129E
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 54 mg/mL; 155.93 mM
Smiles
Cc1c (n2ccccc2c1OC) C (=O) c1cc (c (cc1) N) C (=O) [O-].[Na+]
Molecular Formula
C18H15N2O4·Na
Molecular Weight
346.31
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Sodium 2-amino-5- (1-methoxy-2-methylindolizine-3-carbonyl) benzoate
Available Sizes
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