S- (+) -Rolipram
S- (+) -Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer. (In Vitro) : (+) -Rolipram (0.015-1000 μM; 20 h) dose-dependently suppress LPS-induced TNF production of human mononuclear cells (MNC), with an IC50 of 550 nM. (In Vivo) : (+) -Rolipram (0.025-6.25 mg/kg; a single i.p.) dose-dependently inhibits locomotor activity and induces head twitches in rats. (+) -Rolipram (0.06-25 mg/kg; a single i.p.) causes a dose-related fall in rectal temperature of rats.
Product Specifications
CAS Number
85416-73-5
Product Name Alternative
(+) -Rolipram | (S) -Rolipram
Purity
>98% (HPLC)
Solubility
DMSO : 100 mg/mL. 363.19 mM
Smiles
COC1=C (OC2CCCC2) C=C (C=C1) [C@H]1CNC (=O) C1
Molecular Formula
C16H21NO3
Molecular Weight
275.34
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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