GSK429286A
GSK429286A is a selective Rho-kinase inhibitor (IC50 values are 14, 780 and 1940 nM for ROCK1, RSK and p70S6K respectively) . Reverses adrenalin-induced contraction of the rat aortic ring (IC50 = 190 nM) and causes a dose-dependent decrease in mean arterial blood pressure in spontaneous hypertensive rats. Orally active.
Product Specifications
CAS Number
864082-47-3
Product Name Alternative
GSK429286A | GSK 429286A
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 51 mg/mL; 117.95 mM
Smiles
CC1=C (C (CC (=O) N1) c1ccc (cc1) C (F) (F) F) C (=O) Nc1c (cc2c (c1) cn[nH]2) F
Molecular Formula
C21H16F4N4O2
Molecular Weight
432.37
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (6-fluoro-1H-indazol-5-yl) -2-methyl-6-oxo-4- (4- (trifluoromethyl) phenyl) -1,4,5,6-tetrahydropyridine-3-carboxamide
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