PCI-27483
PCI-27483 is a reversible small-molecule inhibitor of activated factor VII (factor VIIa) with potential antineoplastic and antithrombotic activities. FVII, a serine protease, becomes activated (FVIIa) upon binding with TF forming the FVIIa/TF complex, which induces intracellular signaling pathways by activating protease activated receptor 2 (PAR-2) . Upon subcutaneous administration, factor VIIa inhibitor PCI-27483 selectively inhibits factor FVIIa in the VIIa/TF complex, which may prevent PAR-2 activation and PAR2-mediated signal transduction pathways, thereby inhibiting tumor cell proliferation, angiogenesis, and metastasis of TF-overexpressing tumor cells.
Product Specifications
CAS Number
871266-63-6
Product Name Alternative
PCI27483 | PCI-27483 | PCI 27483
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 62.5 mg/mL (104.77 mM)
Smiles
C1cc2c (cc1C (=N) N) [nH]c (c1cc (cc (c1O) c1c (ccc (c1) S (=O) (=O) N) O) CC (=O) NC (CC (=O) O) C (=O) O) n2
Molecular Formula
C26H24N6O9S
Molecular Weight
596.57
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(S) -2- (2- (5- (5-carbamimidoyl-1H-benzo[d]imidazol-2-yl) -2',6-dihydroxy-5'-sulfamoyl-[1,1'-biphenyl]-3-yl) acetamido) succinic acid.
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