CTEP
CTEP, also known as RO4956371, is a potent, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM. CTEP binds mGlu5 with low nanomolar affinity and shows >1000-fold selectivity when tested against 103 targets, including all known mGlu receptors. CTEP penetrates the brain with a brain/plasma ratio of 2.6 and displaces the tracer ABP688 in vivo in mice from brain regions expressing mGlu5 with an average ED (50) equivalent to a drug concentration of 77.5 ng/g in brain tissue.
Product Specifications
CAS Number
871362-31-1
Product Name Alternative
RO4956371 | RO-4956371 | RO 4956371 | CTEP
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 100 mg/mL. 255.25 mM; H2O : < 0.1 mg/mL
Smiles
CC1=NC (C#CC2=CC=NC (Cl) =C2) =C (C) N1C1=CC=C (OC (F) (F) F) C=C1
Molecular Formula
C19H13ClF3N3O
Molecular Weight
391.77
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-chloro-4-[2-[2,5-dimethyl-1-[4- (trifluoromethoxy) phenyl]imidazol-4-yl]ethynyl]pyridine
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