ML221
ML221 is a potent apelin /APJ functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.
Product Specifications
CAS Number
877636-42-5
Product Name Alternative
ML221 | ML 221 | ML-221
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 31 mg/mL; 80.45 mM
Smiles
C1=CN=C (N=C1) SCC2=CC (=O) C (=CO2) OC (=O) C3=CC=C (C=C3) [N+] (=O) [O-]
Molecular Formula
C17H11N3O6S
Molecular Weight
385.35
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
[4-oxo-6- (pyrimidin-2-ylsulfanylmethyl) pyran-3-yl] 4-nitrobenzoate
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