ML348
ML348, also known as CID 3238952; SID 160654487, is a reversible LYPLA1 inhibitor with an IC50 value of 210 nM. Multiple oncogenes, including HRAS and SRC, require palmitoylation for malignant transformation. Lysophospholipase 1 (LYPLA1) has been identified as a candidate protein palmitoyl thioesterase responsible for HRAS depalmitoylation in mammalian cells. (In Vitro) :ML348 (5 μM; 3 hours) selectively inhibits LYPLA1 in cultured cells. (In Vivo) :ML348 (50 mg/kg, i.p., 3 hours) shows potent and selective activity in vivo, inhibits LYPLA1 enzymes in heart, kidney and lung in mice.
Product Specifications
CAS Number
899713-86-1
Product Name Alternative
ML348 | ML-348 | CID 3238952 | SID 160654487
Purity
>98% (HPLC)
Solubility
DMSO : 25 mg/mL. 60.13 mM
Smiles
N1 (CCN (CC (=O) Nc2c (ccc (c2) C (F) (F) F) Cl) CC1) C (=O) c1ccco1
Molecular Formula
C18H17ClF3N3O3
Molecular Weight
415.79
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N-[2-chloro-5- (trifluoromethyl) phenyl]-4- (2-furanylcarbonyl) -1-piperazineacetamide
Available Sizes
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