BMS-582949 HCl

The BMS-582949 hydrochloride is a highly specific p38α MAPK inhibitor (IC50: 13 nM) . (In Vitro) :BMS-582949 displays a p38α IC50 of 13 nM and a cellular TNFα IC50 of 50 nM.BMS-582949 is a weak inhibitor of CYP3A4 BMS-582949 displays >2000-fold selectivity for p38α over a diverse panel of 57 kinases that include serine kinases, nonreceptor tyrosine kinases, receptor tyrosine kinases, and the p38γ and δ isoforms. (In Vivo) :BMS-582949 (5-100 mg/kg, orally) is effective in both the acute murine model of inflammation and rat adjuvant arthritis model despite its slightly reduced potency.