AOB2796
AC-55541 is a protease-activated receptor (PAR) 2 agonist. AC-55541activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca (2+) mobilization assays, with potencies ranging from 200 to 1000 nM. AC-55541 was well absorbed when administered intraperitoneally to rats, each reaching micromolar peak plasma concentrations. AC-55541 was stable to metabolism by liver microsomes and maintained sustained exposure in rats, with elimination half-lives of 6.1. Systemic administration of either AC-55541 or AC-264613 produced a similar degree of hyperalgesia as was observed when the compounds were administered locally. AC-55541 may be useful in probing the physiological functions of PAR2 receptors.
Product Specifications
CAS Number
916170-19-9
Product Name Alternative
AC-55541 | AC 55541 | AC55541
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 51 mg/mL; ;98.39 mM
Smiles
C/C (=N\NC (=O) C (c1n[nH]c (=O) c2ccccc12) NC (=O) c1ccccc1) /c1cc (ccc1) Br
Molecular Formula
C25H20BrN5O3
Molecular Weight
518.36
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(E) -N- (2- (2- (1- (3-bromophenyl) ethylidene) hydrazinyl) -2-oxo-1- (4-oxo-3,4-dihydrophthalazin-1-yl) ethyl) benzamide
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