AZD1283
AZD1283 is a potent antagonist of the P2Y12 receptor. In a modified Folts model in dog, both AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregation with antithrombotic ED50 values of 3.0 μg/kg/min. The doses that induced a larger than 3-fold increase in bleeding time were 33 μg/kg/min. Thus, the therapeutic index (TI) was ≥ 10. On the basis of these data, AZD1283 was progressed into human clinical trials as candidate drug.
Product Specifications
CAS Number
919351-41-0
Product Name Alternative
AZD-1283 | AZD1283 | AZD 1283
Purity
>98% (HPLC)
Solubility
DMSO : 100 mg/mL. 212.52 mM; H2O : < 0.1 mg/mL
Smiles
CCOC (=O) c1c (nc (c (c1) C#N) N1CCC (CC1) C (=O) NS (=O) (=O) Cc1ccccc1) C
Molecular Formula
C23H26N4O5S
Molecular Weight
470.54
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Ethyl 6- (4- ((benzylsulfonyl) carbamoyl) piperidin-1-yl) -5-cyano-2-methylnicotinate.
Available Sizes
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