Motolimod
Motolimod, also known as VTX-2337, is a small-molecule Toll-like receptor 8 (TLR8) agonist with potential immunostimulating and antineoplastic activities. TLR8 agonist VTX-2337 binds to TLR8, present in cutaneous dendritic cells, monocytes/macrophages, and mast cells, which may result in the activation of the central transcription factor nuclear factor-B, the secretion of proinflammatory cytokines and other mediators, and a Th1-weighted antitumoral cellular immune response. Primarily localized to endosomal membranes intracellularly, TLR8, like other TLRs, recognizes pathogen-associated molecular patterns (PAMPs) and plays a key role in the innate immune system.
Product Specifications
CAS Number
926927-61-9
Product Name Alternative
VTX-2337 | VTX 2337 | VTX2337 | Motolimod
Purity
>98% (HPLC)
Solubility
DMSO : 50 mg/mL. 109.03 mM
Smiles
CCCN (CCC) C (=O) C1=Cc2c (cc (cc2) c2ccc (cc2) C (=O) N2CCCC2) N=C (N) C1
Molecular Formula
C28H34N4O2
Molecular Weight
458.6
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-amino-N, N-dipropyl-8- (4- (pyrrolidine-1-carbonyl) phenyl) -3H-benzo[b]azepine-4-carboxamide
Available Sizes
Frequently Asked Questions
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