Irbinitinib
Tucatinib, also known as Irbinitinib, ARRY-380 and ONT-380, is a n orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.
Product Specifications
CAS Number
937263-43-9
Product Name Alternative
ARRY380 | ARRY 380 | ONT-380. Irbinitinib | Tucatinib
Purity
>98% (HPLC)
Solubility
DMSO : 50 mg/mL. 104.05 mM
Smiles
Cc1c (ccc (c1) Nc1ncnc2c1cc (cc2) NC1=NC (CO1) (C) C) Oc1cc2ncnn2cc1
Molecular Formula
C26H24N8O2
Molecular Weight
480.52
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N6- (4,4-Dimethyl-4,5-dihydrooxazol-2-yl) -N4- (3-methyl-4- ((1,2,4) triazolo (1,5-a) pyridin-7-yloxy) phenyl) quinazoline-4,6-diamine
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