Splitomicin
Splitomicin is a cell-permeable lactone derived from naphthol and known to be a potent selective inhibitor of Sir2 (silent information regulator 2) and HDAC. Splitomicin inhibits the NAD+-dependent deacetylase activity of Sir2 in vitro. It increases the levels of cyclic AMP by inhibiting the activity of cyclic AMP phosphodiesterase, interferes with mobilization of intracellular Ca+2 and ATP release.
Product Specifications
CAS Number
5690-03-9
Product Name Alternative
Splitomicin
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (504.49 mM)
Smiles
O=C1CCc2c3ccccc3ccc2O1
Molecular Formula
C13H10O2
Molecular Weight
198.22
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-benzo[f]chromen-3 (2H) -one
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