MY33-3
MY33-3 is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP) β/ζ, with an IC50 of ~0.1 μM. MY33-3 also inhibits PTP-1B (IC50 ~0.7 μM) . MY33-3 can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction[1][2][3].
Product Specifications
CAS Number
2204280-41-9
UNSPSC
12352005
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/my33-3.html
Purity
99.53
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC(SC1=CC=C(CNCC2=CC=C(SC(F)(F)F)C=C2)C=C1)(F)F
Molecular Formula
C16H13F6NS2
Molecular Weight
397.40
References & Citations
[1]Fernández-Calle R, et, al. Pharmacological inhibition of Receptor Protein Tyrosine Phosphatase β/ζ (PTPRZ1) modulates behavioral responses to ethanol. Neuropharmacology. 2018 Jul 15;137:86-95. |[2]Fernández-Calle R, et, al. Role of RPTPβ/ζ in neuroinflammation and microglia-neuron communication. Sci Rep. 2020 Nov 20;10 (1) :20259. |[3]Mao S, et, al. Pleiotrophin Potentiates Sevoflurane Anesthesia-induced Learning Deficits in Mice. J Mol Neurosci. 2022 Jan;72 (1) :48-55.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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