YK-4-279

YK-4-279 is a ETV1 inhibitor, which inhibitor protein-protein interactions between ES-FLI1 and RHA.YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model. YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1. YK-4-279, prevents prostate cancer growth and metastasis in a mouse xenograft model. (In Vitro) :YK-4-279 (3-30 μM; overight) dissociates EWS-FLI1 from RHA in Ewing’s sarcoma family tumor (ESFT) cells.YK-4-279 (3-30 μM; 14 h) nearly eliminates cyclin D1 in TC32 cells.YK-4-279 (3-30 μM; 72 h) potently and specifically inhibits ESFTs.YK-4-279 (50 μM; 6 h) induces substantial apoptosis of ESFT cells.YK-4-279 (0.1-30 μM; 72 h) inhibits the growth of ESFT, prostate, breast and pancreatic cancer cells. (In Vivo) :YK-4-279 (1.5 mg; i.p. once) inhibited ESFT tumor growth.