Cinnamaldehyde

Cinnamaldehyde has antipyretic activity. Cinnamaldehyde is a sedative agent. Cinnamaldehyde inhibits invasive capabilities of MDA-MB-435S cells was correlated with down-regulating the expression of miR-27a. Cinnamaldehyde induces the generation of reactive oxygen species and exerts vasodilator and anticancer effects. Cinnamaldehyde appears to be a promising candidate as an adjuvant in combination therapy with 5-fluorouracil (5-FU) and oxaliplatin (OXA), two chemotherapeutic agents used in CRC treatment. The possible mechanisms of its action may involve the regulation of drugmetabolizing genes. 6. Cinnamaldehyde plays a certain role in inhibiting the occurrence and progression of melanoma and its action mechanism may be manifested by inhibiting expression of VEGF and HIF-α, thus blood vessel simulation and formation of new blood vessels of melanoma cells, and growth of tumors accordingly. (In Vitro) :trans-cinnamaldehyde -β-cyclodextrin complex against Salmonella spp. and Lis-teria spp. with minimum inhibitory concentrations ranging from 10 to 20 mg/mL, respectively.