Apoptozole
Apoptozole, also known as Apoptosis Activator VII, is a selective inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity. Apoptozole enhances immune responses to administered antigens. Treatment of mice with Apoptozole elicits production of antibodies with a high IgG2c/IgG1 ratio and stimulates the release of Th1 and Th2-type cytokines, suggesting that Apoptozole activates the Th1 and Th2 immune responses. The ATPase activities of Hsp70 and Hsc70 are known to be responsible for regulation of various biological processes.
Product Specifications
CAS Number
1054543-47-3
Product Name Alternative
Apoptozole | Apoptosis Activator VII
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 31 mg/mL; 49.56 mM
Smiles
COC1=CC=C (C=C1) C2=C (N (C (=N2) C3=CC (=CC (=C3) C (F) (F) F) C (F) (F) F) CC4=CC=C (C=C4) C (=O) N) C5=CC=C (C=C5) OC
Molecular Formula
C33H25F6N3O3
Molecular Weight
625.56
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4- ((2- (3,5-bis (trifluoromethyl) phenyl) -4,5-bis (4-methoxyphenyl) -1H-imidazol-1-yl) methyl) benzamide
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