Aprindine (hydrochloride)
Aprindine hydrochloride is an Ib-class anti-arrhythmic agent. Aprindine hydrochloride mainly exerts its effect by blocking sodium channels (INa), thereby reducing the excitability and conduction velocity of cardiac muscle cells. Aprindine hydrochloride significantly inhibits delayed potassium currents, which helps to prolong the atrial effective refractory period (AERP) and inhibit the occurrence of atrial fibrillation. Aprindine hydrochloride can also regulate intracellular calcium ion concentration by inhibiting Na+/Ca2+ exchange current (INCX), thereby further stabilizing cardiac electrical activity. Aprindine hydrochloride can be used for the study of atrial fibrillation (AF) and ventricular arrhythmias[1][2][3][4].
Product Specifications
CAS Number
33237-74-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Calcium Channel; Calmodulin; Potassium Channel; Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/aprindine-hydrochloride.html
Concentration
10mM
Purity
98.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCN(CC)CCCN(C1CC2=C(C=CC=C2)C1)C3=CC=CC=C3.[H]Cl
Molecular Formula
C22H31ClN2
Molecular Weight
358.95
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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