Tretazicar
Tretazicar (CB1954) is a dinitrobenzamide prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide (EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. CB1954 has been proposed for use in enzyme-prodrug gene therapy systems with the Escherichia coli enzyme nitroreductase (Ntr) . Ntr converts CB1954 to 2- and 4-hydroxylamino derivatives, whereupon the non-enzymatic reaction of the 4-hydroxylamino derivative with cellular thio- esters generates a potent cytotoxic bifunctional alkylating agent capable of cross-linking DNA.
Product Specifications
CAS Number
21919-05-1
Product Name Alternative
CB1954 | CB-1954 | CB 1954 | Tretazicar
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 125 mg/mL (495.68 mM)
Smiles
NC (=O) c1c (cc (c (c1) N1CC1) [N+] (=O) [O-]) [N+] (=O) [O-]
Molecular Formula
C9H8N4O5
Molecular Weight
252.18
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5- (aziridin-1-yl) -2,4-dinitrobenzamide
Available Sizes
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