Bisdemethoxycurcumin
Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression.
Product Specifications
CAS Number
24939-16-0
Product Name Alternative
Curcumin III, Bisdemethoxycurcumin
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 66.67 mg/mL (216.23 mM)
Smiles
Oc2ccc (/C=C/C (=O) CC (=O) /C=C/c1ccc (O) cc1) cc2
Molecular Formula
C19H16O4
Molecular Weight
308.33
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(1E,6E) -1,7-Bis (4-hydroxyphenyl) hepta-1,6-diene-3,5-dione
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