PNU 282987
PNU-282987 is a highly selective α7 nAChR agonist (Ki = 26 nM) displaying negligible blockade of α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM) . PNU-282987 is inactive against a panel of 32 receptors at 1 μM, except 5-HT3 receptors (Ki = 930 nM) .
Product Specifications
CAS Number
123464-89-1
Product Name Alternative
PNU-282987 | PNU 282987
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 61 mg/mL 202.52 mM; H2O : 50 mg/mL 166.00 mM
Smiles
Cl.C1CN2CCC1[C@H] (C2) NC (=O) c1ccc (cc1) Cl
Molecular Formula
C14H18Cl2N2O
Molecular Weight
301.21
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, N- (3R) -1-azabicyclo (2.2.2) oct-3-yl-4-chloro-, hydrochloride (1:1)
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