Lutein

Lutein is a xanthophyll found in the major light-harvesting protein complexes of plants. Dietary lutein accumulates in the macula lutea. (In Vitro) :Lutein (100 or 200 μM) protects against A2-PE (a bis-retinoid compound that is the immediate precursor of the lipofuscin fluorophore A2E) photooxidation and reduces A2E photooxidation. (In Vivo) :Lutein (40-160 mg/kg; in diet for 5 weeks) protects against severe traumatic brain injury through anti-inflammation and anti-oxidative effects via ICAM-1/Nrf-2 in rats.Lutein (0.1-10 mg/kg; p.o.; once or daily for 7 and 21 days) prevents Corticosterone (HY-B1618) -induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities.