E3 Ligase Ligand-linker Conjugate 91
Product Specifications
UNSPSC Description
E3 Ligase Ligand-linker Conjugate 91 is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. E3 Ligase Ligand-linker Conjugate 91 can be used as a key intermediate for the synthesis of complete PROTAC molecules.
Target Antigen
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/e3-ligase-ligand-linker-conjugate-91.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)NC(COCCN2CCN(CC2)C(OC(C)(C)C)=O)=O)=O)NCC(C=C3)=CC=C3C(SC=N4)=C4C
Molecular Weight
700.89
References & Citations
[1]Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres.1236.2019.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157634/E3-Ligase-Ligand-linker-Conjugate-91-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157634/
Clinical Information
No Development Reported
CAS Number
2229713-40-8
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Rabbit Polyclonal FNIP1 Antibody [Alexa Fluor 594]](https://cdn.genprice.uk/genprice/genprice4.png)
