Buclizine HCl
Buclizine HCl is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine binds to and blocks the histamine H1 receptor, thereby preventing the symptoms that are caused by histamine activity. Buclizine exerts its anti-emetic effect by binding to and blocking the muscarinic and histamine receptors in the vomiting center of the central nervous system (CNS) . This may prevent activation of the chemoreceptor trigger zone (CTZ) and may reduce nausea and vomiting.
Product Specifications
CAS Number
129-74-8
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 2.5 mg/mL (4.94 mM)
Smiles
CC (C) (C) c1ccc (cc1) CN1CCN (CC1) C (c1ccccc1) c1ccc (cc1) Cl.Cl.Cl
Molecular Formula
C28H33ClN2·2HCl
Molecular Weight
505.95
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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