BMS-3
BMS-3 is a LIM kinase 1 (LIMK1) inhibitor. LIMK inhibition with 1 μM BMS-3 damaged MTOC protein localisation to spindle poles, undermined the formation and positioning of functional MTOC and thus disrupted spindle formation and chromosome alignment. These effects were phenocopied by microinjection of LIMK1 antibody into mouse oocytes. LIM kinase 1 (LIMK1) activity is essential for cell migration and cell cycle progression.
Product Specifications
CAS Number
1338247-30-5
Product Name Alternative
BMS-3 | BMS 3 | BMS3
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 30 mg/mL6; 9.89 mM
Smiles
O=C (Nc1ncc (s1) c2cc (nn2c3c (Cl) cccc3Cl) C (F) F) C4CC4
Molecular Formula
C17H12Cl2F2N4OS
Molecular Weight
429.27
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N-[5-[2- (2,6-Dichlorophenyl) -5- (difluoromethyl) pyrazol-3-yl]-1,3-thiazol-2-yl]cyclopropanecarboxamide
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