GSK J1
GSKJ1 is a selective and potent histone demethylase inhibitor (GSK-J1) that has significant activity (IC50 60 nM for human JmjD3) in vitro and in cells using an ester derivative (GSK-J4: 1 μM 100 μM for human JmjD3) and thus can be used as control for target effects in vitro, and as ester derivative (GSK-J5) in cells. Recent data has shown that GSK-J1 also shows some activity (IC50 950 nM for Jarid1b, IC50 1.76 uM for Jarid1c) against H3K4me3/2/1 demethylases.
Product Specifications
CAS Number
1373422-53-7
Product Name Alternative
GSKJ1 | GSKJ 1 | GSKJ-1
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 33 mg/mL; 84.73 mM
Smiles
OC (=O) CCNC1=CC (=NC (=N1) C1=CC=CC=N1) N1CCC2=C (CC1) C=CC=C2
Molecular Formula
C22H23N5O2
Molecular Weight
389.45
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3- ((2- (pyridin-2-yl) -6- (1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl) pyrimidin-4-yl) amino) propanoic acid
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