Negletein
Negletein has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows a comparable redox-active potential, and it (50 μM, 4 h) can activate Nrf2. Negletein shows significant antimicrobial activity. Negletein has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.Negletein has anti- Alzheimer's disease activity, it inhibits the iron-dependent formation of ROS and also blocks the iron-induced oligomerization of amyloid beta 42 in vitro. Negletein (IC50: 3.89 +/- 0.39 microM) exhibits potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor.
Product Specifications
CAS Number
29550-13-8
Product Name Alternative
Negletein
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (351.79 mM)
Smiles
COC1=C (C (=C2C (=C1) OC (=CC2=O) C3=CC=CC=C3) O) O
Molecular Formula
C16H12O5
Molecular Weight
284.26
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4H-1-Benzopyran-4-one, 5,6-dihydroxy-7-methoxy-2-phenyl-
Available Sizes
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