Ingenol
Ingenol is a diterpenoid related to phorbol, derived from the milkweed plant E. peplus. Most ingenol esters are tumor-promoting. However, ingenol mebutate possesses anti-tumor activity when used topically for actinic keratosis. (In Vitro) :Ingenol is a PKC activator, with a Ki of 30 μM. Ingenol induces ornithine decarboxylase activity (1, 3 mM), and causes morphological changes (1 mM) in primary mouse epidermal keratinocytes. Ingenol (125 μM, 250 μM, 500 μM, 1 mM) also inhibits cell-cell communication.
Product Specifications
CAS Number
30220-46-3
Product Name Alternative
Ingenol
Purity
>98% (HPLC)
Solubility
DMSO : 100 mg/mL 287.00 mM
Smiles
CC1CC2C (C2 (C) C) C3C=C (C (C4 (C1 (C3=O) C=C (C4O) C) O) O) CO
Molecular Formula
C20H28O5
Molecular Weight
348.43
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(1aR,2S,5R,5aR,6S,8aS,9R,10aR) -5,5a,6-trihydroxy-4- (hydroxymethyl) -1,1,7,9-tetramethyl-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e][10]annulen-11-one
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