Magic™ Membrane Protein Human BDKRB2 (Bradykinin receptor B2)

The B2R is a receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. The B2 receptor mediates slow contraction of various smooth muscles including veins, intestine, uterus, trachea and lung, inducing endothelium-dependent relaxation of aRoom Temperatureeries and aRoom Temperatureerioles, and stimulates natriuresis/diuresis in kidney. The B2 receptor couples to Gq and Gi, Gq stimulates phospholipase C to increase intracellular free calcium and Gi inhibits adenylate cyclase. FuRoom Temperaturehermore, the receptor stimulates the mitogen-activated protein kinase pathways. The B2 receptor also forms a complex with angiotensin conveRoom Temperatureing enzyme (ACE) and this is thought to play a role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS).