CLOZAPINE N-OXIDE
Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration. It is produced by the action of cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4, whose activities, in turn, can be affected by drugs and disease. Clozapine N-oxide is normally biologically inactive. However, it can be used in designer receptor exclusively activated by designer drugs, also known as DREADDs, technology to modulate synthetic receptors in vivo.
Product Specifications
CAS Number
34233-69-7
Product Name Alternative
Clozapine N-oxide
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 100 mg/mL 291.70 mM; Methanol : ≥ 28.6 mg/mL 83.43 mM H2O : 1 mg/mL 2.92 mM
Smiles
Clc1ccc2Nc4ccccc4C (=Nc2c1) N3CC[N+] ([O-]) (C) CC3
Molecular Formula
C18H19ClN4O
Molecular Weight
342.82
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3-Chloro-6- (4-methyl-4-oxidopiperazin-4-ium-1-yl) -5H-benzo[b][1,4]benzodiazepine
Available Sizes
Frequently Asked Questions
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