Palmatine

Palmatine is an inhibitor of dopamine generation. Palmatine could potentially be developed for the treatment of flavivirus infections. Palmatine has been used in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases. (In Vitro) :Palmatine (0-100 μM; 42 h) suppresses WNV with an EC50 value of 3.6 μM, and reduce the viral titers of DENV-2 and YFV with EC50 values of 26.4 μM and 7.3 μM, respectively.Palmatine (0-1128 μM; 24-72 h) inhibits colon cancer cell proliferation.Palmatine (0-704 μM; 24 h) reduces AURKA protein levels, induces G2/M phase arrest, and induces apoptosis in colon cancer cells via the mitochondrial associated pathway. (In Vivo) :Palmatine (50 or 100 mg/kg; p.o.; daily for 7 days) ameliorates DSS (dextran sulfate sodium) -induced colitis and prevents infiltration of inflammatory cells.Palmatine (0-200 mg/kg; i.p.; once) attenuates D-galactosamine/Lipopolysaccharides (HY-D1056) -induced fulminant hepatic failure in mice.Palmatine (0-1 mg/kg; i.p.; 10 days) shows memory-enhancing activity in mice.Palmatine (33.75-135 mg/kg; p.o.; daily for 26 days) can effectively inhibit the growth of HCT-116 xenografts in mice.