CAY10602
CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells, with approximately 75% inhibition achieved at 60 μM, without cytotoxicity.
Product Specifications
CAS Number
374922-43-7
Product Name Alternative
CAY10602 | CAY-10602 | CAY 10602
Purity
>98% (HPLC)
Solubility
DMSO : 100 mg/mL 238.98 mM
Smiles
Fc1ccc (cc1) n1c2nc3ccccc3nc2c (c1N) S (=O) (=O) c1ccccc1
Molecular Formula
C22H15FN4O2S
Molecular Weight
418.44
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1- (4-fluorophenyl) -3- (phenylsulfonyl) -1H-pyrrolo[2,3-b]quinoxalin-2-amine
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