TCS-PIM-1-4a
SMI-4a is a potent and selective Pim protein kinase inhibitor, which blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. SMI-4a was found to induce phosphorylation of extracellular signal-related kinase1/2 (ERK1/2), and the combination of SMI-4a and a mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor was highly synergistic in killing pre-T-LBL cells. SMI-4a may be developed as a therapeutic strategy for the treatment of pre-T-LBL.
Product Specifications
CAS Number
438190-29-5
Product Name Alternative
SMI-4a | SMI4a | SMI 4a | TCS PIM-1 4a.
Field of Research
Cell Biology
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : ≥ 100 mg/mL (365.99 mM)
Smiles
C1cc (cc (c1) C (F) (F) F) /C=C\1/C (=O) NC (=O) S1
Molecular Formula
C11H6F3NO2S
Molecular Weight
273.23
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5- (3- (trifluoromethyl) benzylidene) thiazolidine-2,4-dione
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