NS1643
NS-1643 is a Human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM) . NS1643 increased both steady-state and tail current at all voltages tested. The EC (50) value for HERG channel activation was 10.5 microM. HERG channel activation by small molecules such as NS1643 increases the repolarization reserve and presents an interesting new antiarrhythmic approach.
Product Specifications
CAS Number
448895-37-2
Product Name Alternative
NS-1643 | NS 1643 | NS1643
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 100 mg/mL; 262.99 mM
Smiles
C1c (ccc (c1NC (=O) Nc1c (O) ccc (c1) C (F) (F) F) O) C (F) (F) F
Molecular Formula
C15H10F6N2O3
Molecular Weight
380.24
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1,3-bis (2-hydroxy-5- (trifluoromethyl) phenyl) urea
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